Author

Tsuyoshi Hirota

Institute of Transformative Bio-MoleculesORCID 0000-0003-4876-3608Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Steve A. KayiD· 2 shared Anahit Hovsepyan· 1 shared Gevorg Karapetyan· 1 shared Jamie Cope· 1 shared Jeremy N. RichiD· 1 shared Jiarui WangiD· 1 shared Laura A. SoltiD· 1 shared Meng QuiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Steve A. KayORCID

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2 papers

Recent·Most cited

Cancer BiologyNeuro-OncologyPeer-reviewedApr 1, 2025

Advancing Clinical Response Against Glioblastoma: Evaluating SHP1705 CRY2 Activator Efficacy in Preclinical Models and Safety in Phase I Trials

Priscilla Chan, Yoshiko Nagai, Qiulian Wu…·Steve A. Kay

This paper evaluates the safety and efficacy of SHP1705, a CRY2 activator, in preclinical models and Phase I trials, showing improved efficacy against GBM stem cells and synergistic effects with a REV-ERB agonist.

19 citationstop 2%

humanbulk RNA-seq

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Molecular BiologyProceedings of the National Academy of SciencesPeer-reviewedDec 10, 2018

Nuclear receptor HNF4A trans-represses CLOCK:BMAL1 and acts as a core component of tissue-specific circadian networks

Meng Qu, Tomas Duffy, Tsuyoshi Hirota, Steve A. Kay

This study shows HNF4A trans-represses CLOCK:BMAL1 and is a core component of tissue-specific circadian networks in liver and colon cells.

83 citationstop 4%

mouseDNA methylation

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