Jian You Lau

This study models how 3D confinement affects RNA folding and circularization in the Zika virus genome, showing increased circularization under confinement.

The paper identifies molecular domains in the U8 snoRNA affected by LCC mutations and shows how U8 function impacts stability through a post-transcriptional mechanism.

The paper introduces HiCapR, a method to map HIV-1 RNA structures, homodimers, and long-range interactions, revealing new insights into RNA organization and its role in viral processes.

The paper maps RNA homodimers in living cells using proximity ligation methods, revealing their rarity across the transcriptome and enrichment in specific RNAs and viral genomes.

The paper investigates the structural features of the NORAD lncRNA and their role in modulating Pumilio protein activity through RNA structure and interactions.

This study maps the in vivo RNA-RNA interactome of SARS-CoV-2 during its life cycle, revealing structural features and dynamics that regulate replication, transcription, and frameshifting.