Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators
Bina Desai, Tatiana Miti, Sandhya Prabhakaran, Daria Miroshnychenko, Pragya Kumar, Menkara Henry, Viktoriya Marusyk, Natália Souza Nunes Siqueira, Chandler Gatenbee, Hilal Özakıncı, Marilyn Bui, Theresa A. Boyle, Jacob Scott, Philipp M. Altrock, Bruna Pellini, , Andriy Marusyk
This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.
Nature Communications · May 29, 2026Peer-reviewedCancer Biology