Chandler Gatenbee

Lymphoma response to chimeric antigen receptor T cell therapy is driven by endogenous tumor-reactive CD8⁺ T cells

This study shows that durable CAR-T therapy in lymphoma requires cooperation with endogenous CD8 T cells, and tumors lacking MHC class I or CD58 resist treatment.

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

Controlling treatment toxicity in ovarian cancer to prime the patient for tumor extinction therapy

This paper develops computational frameworks to design personalized multi-strike therapies for ovarian cancer that reduce toxicity while enhancing tumor extinction.

Integrating diverse statistical methods to analyse stage-discriminatory cell interactions in colorectal neoplasia

The paper develops spatial descriptors using mathematical tools to analyze cell interactions in colorectal cancer progression and demonstrates their utility in identifying disease-related pathways.

NeoPredPipe: High-Throughput Neoantigen Prediction and Recognition Potential Pipeline

NeoPredPipe predicts and assesses neoantigen recognition potential from tumor variants in single and multi-region samples, providing insights into neoantigen burden and tumor heterogeneity.

Hybrid Automata Library: A modular platform for efficient hybrid modeling with real-time visualization

The paper introduces the Hybrid Automata Library (HAL), a Java platform for building hybrid models in mathematical oncology, with real-time visualization and modular components.

Connecting the Microenvironmental Niche to Treatment Response in Ovarian Cancer

This study develops a mathematical model to analyze spatial interactions in ovarian cancer microenvironments and shows how niche composition affects treatment response.