Jingyi Wang

BART-spatial identifies transcriptional regulators from spatial omics data by integrating spatial and pseudotemporal information with TR binding profiles, outperforming existing methods.

BARTsc identifies key transcriptional regulators from single-cell omics data by integrating ChIP-seq profiles and outperforms existing methods in multiple biological systems.

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.