Rama D Natarajan

This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

The paper identifies DNA methylation changes linked to cumulative hyperglycaemia in type 1 diabetes and links some to diabetic kidney disease through Mendelian randomization.

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.

The paper identifies DNA methylation biomarkers associated with diabetic kidney disease progression in type 1 diabetes using a prospective cohort study.

The paper identifies mitochondrial RNAs (mtRNAs) as chromatin-associated RNAs (caRNAs) that regulate nuclear transcription in response to stress and disease.

The paper investigates how RNA-chromatin interactions change in endothelial cells under high-glucose and TNF treatment, showing their role in inflammation and endothelial dysfunction.

This study shows that Epstein-Barr virus transforms B cells to activate LTR enhancers and promoters, altering the transcriptome and impacting oncogenic processes.

The paper identifies transposable elements (TEs) as contributors to chromatin accessibility variation in mice liver, linking TE polymorphism and DNA methylation to metabolic pathway differences.