Author

Vajir Malek

City Of Hope National Medical CenterORCID 0000-0003-3680-058XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Linda L. LantingiD· 2 shared Marpadga A. ReddyiD· 2 shared Rama D NatarajaniD· 2 shared Vinay Singh TanwariD· 2 shared Zhen CheniD· 2 shared Chongzhi ZangiD· 1 shared Clint L. MilleriD· 1 shared Hongpan ZhangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenomics

Linda L. LantingORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 8, 2026

Epigenome Alterations and 3D Chromatin Architecture Remodeling in Inflammatory Macrophage Activation under Diabetic Conditions

Marpadga A. Reddy, S. Bhattacharya, Vinay Singh Tanwar…·Rama Natarajan

This study investigates how diabetic conditions alter the 3D chromatin architecture and epigenome of macrophages, revealing disease-associated rewiring of the 3D epigenome and potential therapeutic targets.

DOI 10.64898/2026.05.27.727961

humanbulk RNA-seq

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BiochemistryArteriosclerosis Thrombosis and Vascular BiologyPeer-reviewedFeb 5, 2026

Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control

Vinay Singh Tanwar, Vajir Malek, Jingyi Wang…·Rama D Natarajan

This study uses single-cell multi-omics to show that diabetic mice show persistent aortic smooth muscle cell dysfunction and phenotypic changes despite glycemic control, with partial reversal by dapagliflozin.

5 citationstop 1%

mousescRNA-seq

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