BiophysicsbioRxivPreprint
Disordered activation domains enhance DNA target search rate of a bZIP transcription factor
Jeremie Gaudez, Sarah L. Shammas
This study shows that disordered activation domains of CREB reduce its non-specific DNA binding, enhancing target search efficiency by limiting sequestration on non-target DNA.
DOI 10.1101/2025.11.15.688632