Sarah L. Shammas

This study shows that disordered activation domains of CREB reduce its non-specific DNA binding, enhancing target search efficiency by limiting sequestration on non-target DNA.

This study shows that CREB basic zippers preferentially search DNA targets as dimers rather than monomers, with dimeric complexes being more efficient in binding DNA.

This study examines the transition state of DNA binding in disordered bZIP domains and finds it resembles the unbound state, challenging predictions of disorder-mediated rate enhancement.