NeurosciencebioRxivPreprint
Genotype-Phenotype Distinctions in Spastic Paraplegia 4 Reveal HDAC6 as a Therapeutic Target
Neha Mohan, Skandha Ramakrishnan, Xiaohuan Sun…·Liang Qiang
This study uses isogenic hiPSC-derived motor cortical organoids to identify HDAC6 hyperactivation as a key driver of SPG4 pathology and a potential therapeutic target.
DOI 10.1101/2025.07.15.664947