Author

Anastasia Spinou

Princess Máxima CenterORCID 0009-0000-1862-3140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Jarno DrostiD· 1 shared Patrick KemmereniD· 1 shared Richard GremmeniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Jarno DrostORCID

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1 paper

Recent·Most cited

BioinformaticsBMC Medical GenomicsPeer-reviewedDec 12, 2025

A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer

Anastasia Spinou, Richard Gremmen, Jarno Drost, Patrick Kemmeren

The paper introduces PIGI, a pathway-informed framework to detect genetic interactions in pediatric cancer, identifying 35 new candidate gene pairs with potential synthetic lethal interactions.

DOI 10.1186/s12920-025-02289-z

humanwhole-exome sequencing

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