Author

Richard Gremmen

Princess Máxima CenterORCID 0009-0003-1494-8847Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Anastasia SpinouiD· 1 shared Anna-Karina FelderiD· 1 shared Emile van den AkkeriD· 1 shared Han J. M. P. VerhageniD· 1 shared Jarno DrostiD· 1 shared Marjon J.A.M. Verstegen· 1 shared Patrick KemmereniD· 1 shared Peter H.L. KrijgeriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBioinformatics

Anastasia SpinouORCID

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2 papers

Recent·Most cited

BioinformaticsBMC Medical GenomicsPeer-reviewedDec 12, 2025

A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer

Anastasia Spinou, Richard Gremmen, Jarno Drost, Patrick Kemmeren

The paper introduces PIGI, a pathway-informed framework to detect genetic interactions in pediatric cancer, identifying 35 new candidate gene pairs with potential synthetic lethal interactions.

DOI 10.1186/s12920-025-02289-z

humanwhole-exome sequencing

𝕏 PostBluesky

Molecular BiologybioRxivPreprintJan 13, 2025

Reactivation of developmentally silenced globin genes through genomic deletions reveals that enhancer distance matters

Anna-Karina Felder, Sjoerd J. D. Tjalsma, Han J. M. P. Verhagen…·Wouter L. de Laat

The paper shows that deleting intervening DNA can bring enhancers closer to silenced genes, reactivating their expression in adult cells.

3 citations

humanDNA methylation

𝕏 PostBluesky