Author

Pablo San Segundo-Acosta

Spanish National Cancer Research CentreORCID 0009-0000-1951-1423Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Bonnie J. MurphyiD· 1 shared Jasminka BoskoviciD· 1 shared Johanne Le CoqiD· 1 shared P. Bowers· 1 shared Robin A. Aglietti· 1 shared Roger Castells‐GraellsiD· 1 shared Todd O. YeatesiD· 1 shared Victor R. A. DubachiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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1 shared paperBiophysics

Bonnie J. MurphyORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedSep 7, 2026

Design and structure of protein cages based on helical fusion and machine learning

Pablo San Segundo‐Acosta, Johanne Le Coq, Jasminka Boskovic…·Roger Castells‐Graells

The paper designs and validates self-assembling protein cages using helical fusion and machine learning, achieving precise structures with high resolution and molecular mass accuracy.

DOI 10.1021/jacs.6c11491

protein structuremachine learning (classical)

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BiophysicsbioRxivPreprintOct 17, 2023

Structural and mechanistic insights into Streptococcus pneumoniae NADPH oxidase

Victor R. A. Dubach, Pablo San Segundo-Acosta, Bonnie J. Murphy

This study presents cryo-EM structures of Streptococcus pneumoniae NADPH oxidase and elucidates its structural basis for activity, substrate specificity, and catalytic regulation.

DOI 10.1101/2023.10.17.562464

bacteria (other)experimental assay

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