Johanne Le Coq

The paper designs and validates self-assembling protein cages using helical fusion and machine learning, achieving precise structures with high resolution and molecular mass accuracy.

This study identifies CCDC6-RET as a dual ATP/ADP-dependent kinase with a unique dimeric structure and phosphorylation mechanism, revealing structural and functional determinants of its oncogenic activity.

This study shows that loss of CnAβ1 enhances brown adipocyte differentiation and metabolic activity through FoxO1 activation, leading to improved insulin sensitivity and reduced body weight on a high-fat diet.