Author

Kevin Y. Zhang

Howard Hughes Medical InstituteORCID 0009-0000-3646-2395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeff Y. CheniD· 2 shared Wilfred A. van der DonkiD· 2 shared Deborah A. BertholdiD· 1 shared Lingyang ZhuiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

Jeff Y. ChenORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 28, 2026

Mechanism of remarkable peptide modifications by the multinuclear non-heme iron-dependent oxidative enzymes ChrH/DybH

Jeff Y. Chen, Kevin Y. Zhang, Wilfred A. van der Donk

The paper investigates the mechanism of peptide modifications by DybH and ChrH enzymes, identifying key steps in macrocyclization and heterocycle formation through mutational analysis.

DOI 10.64898/2026.10.27.762324

experimental assay

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMar 30, 2026

Co-opting the bacterial lipoprotein pathway in the biosynthesis of a lipidated macrocyclic peptide

Jeff Y. Chen, Lingyang Zhu, Kevin Y. Zhang…·Wilfred A. van der Donk

The paper identifies a new class of lipidated RiPPs that use the bacterial lipoprotein pathway for maturation, showing structural diversity and widespread distribution across bacterial phyla.

4 citationstop 1%

bacteria (other)proteomics

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