Author

Jeff Y. Chen

Howard Hughes Medical InstituteORCID 0000-0002-8507-8215Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:comparative / phylogenetic analysis· 1 Assay:proteomics· 1

Frequent Co-Authors

Wilfred A. van der DonkiD· 3 shared Kevin Y. ZhangiD· 2 shared Lingyang ZhuiD· 2 shared Chandrashekhar PadhiiD· 1 shared Deborah A. BertholdiD· 1 shared Ryan MoreiraiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

Wilfred A. van der DonkORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 28, 2026

Mechanism of remarkable peptide modifications by the multinuclear non-heme iron-dependent oxidative enzymes ChrH/DybH

Jeff Y. Chen, Kevin Y. Zhang, Wilfred A. van der Donk

The paper investigates the mechanism of peptide modifications by DybH and ChrH enzymes, identifying key steps in macrocyclization and heterocycle formation through mutational analysis.

DOI 10.64898/2026.10.27.762324

experimental assay

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMar 30, 2026

Co-opting the bacterial lipoprotein pathway in the biosynthesis of a lipidated macrocyclic peptide

Jeff Y. Chen, Lingyang Zhu, Kevin Y. Zhang…·Wilfred A. van der Donk

The paper identifies a new class of lipidated RiPPs that use the bacterial lipoprotein pathway for maturation, showing structural diversity and widespread distribution across bacterial phyla.

4 citationstop 1%

bacteria (other)proteomics

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BiochemistrybioRxivPreprintApr 4, 2025

Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of ortho-Tyrosines

Chandrashekhar Padhi, Lingyang Zhu, Jeff Y. Chen…·Wilfred A. van der Donk

This study identifies a conserved FHAFRF-motif in precursor peptides of MNIO-encoding BGCs and demonstrates that MNIO and B12-rSAM enzymes catalyze ortho-hydroxylation and crosslinking of phenylalanine residues to form macrocyclic peptides.

2 citations

bacteria (other)experimental assay

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