Author

Ryo Tsuchihashi

Japan Blood Products OrganizationORCID 0009-0000-5093-1151Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1

Frequent Co-Authors

Misaki KinoshitaiD· 2 shared Hiroaki Aino· 1 shared

Activity by Year

2026-2026 · peak 2/yr

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2 top collaborators · 1 mutual co-author link

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2 shared papersBioinformatics

Misaki KinoshitaORCID

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2 papers

Recent·Most cited

BioinformaticsJournal of Chromatography APeer-reviewedJul 29, 2026

De novo design of a peptide ligand for specific affinity purification of human complement C1q

Ryo Tsuchihashi, Misaki Kinoshita, Hiroaki Aino

This paper designs a cyclic peptide ligand using AlphaFold2 for specific purification of human complement C1q from plasma, demonstrating high selectivity and mild elution conditions.

DOI 10.1016/j.chroma.2026.467307

humanprotein structure

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 12, 2026

Cyclic peptides space: The methodology of sequence selection to cover the comprehensive physical properties

Ryo Tsuchihashi, Misaki Kinoshita

The paper introduces a methodology to generate cyclic peptide libraries with uniform coverage of physicochemical properties using a protein language model and cyclic permutation averaging.

DOI 10.64898/2026.03.10.710724

protein sequencestatistical model

𝕏 PostBluesky