Genetic & Genomic MedicinemedRxivPreprint
PARP1 regulates establishment of the ovarian reserve and age at natural menopause
Hannah R. Schorle, Jason Alexander Halliwell, Jonas Damgaard Elsborg…·Eva R. Hoffmann
This study identifies a variant in PARP1 associated with earlier menopause by affecting primordial germ cell fate through altered DNA binding and transcriptional regulation.
DOI 10.1101/2025.06.18.25329841