PARP1 regulates establishment of the ovarian reserve and age at natural menopause
Hannah R. Schorle, Jason Alexander Halliwell, Jonas Damgaard Elsborg, Stasa Stankovic, Emily J Morbey, Jack R A Murzynowski, Amy V. Kaucher, Ruiqi Sun, Michael Lund Nielsen, Kathleen R. Stewart-Morgan, Anna Murray, Jesper Velgaard Olsen, John R. B. Perry, Eva R. Hoffmann
This study identifies a variant in PARP1 associated with earlier menopause by affecting primordial germ cell fate through altered DNA binding and transcriptional regulation.
medRxiv · Jun 18, 2025 · PreprintGenetic & Genomic Medicine