Author

Phillip J. Zhou

Brigham and Women's HospitalORCID 0009-0000-5789-2490Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant effect prediction· 1

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Atharva Tyagi· 1 shared Christopher A. CassaiD· 1 shared David Benjamin AscheriD· 1 shared Felicitas VogdiD· 1 shared Gerald SchwankiD· 1 shared Jayoung RyuiD· 1 shared Jing ZhaoiD· 1 shared Luca PinelloiD· 1 shared

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2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Atharva Tyagi

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1 paper

Recent·Most cited

GeneticsCirculationPeer-reviewedSep 1, 2026

LDLR variant classification through activity-normalized prime editing screening

Phillip J. Zhou, Minja Velimirovic, Yu Tian…·Richard I. Sherwood

This paper uses prime editing to classify LDLR variants by measuring their impact on LDL-C uptake, reclassifying many previously unclassified variants.

DOI 10.1161/circulationaha.125.078585

humanCRISPR screen

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