Author

Siddharth Nimkar

Indian Institute of Technology GuwahatiORCID 0009-0000-9594-0457Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Baskaran AnandiD· 1 shared Deepti KaranduriD· 1 shared John KuriyaniD· 1 shared Mike E. O’DonnelliD· 1 shared Subu K. SubramanianiD· 1 shared Thu NguyeniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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1 shared paperMolecular Biology

Baskaran AnandORCID

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2 papers

Recent·Most cited

BiochemistryMolecular Biology and EvolutionPeer-reviewedAug 14, 2026

Redesign of energetically frustrated regions rescues function in defective T4 clamp loaders

Siddharth Nimkar, Thu Nguyen, Deepti Karandur…·John Kuriyan

The paper identifies and redesigns energetically frustrated regions in a defective T4 clamp loader to restore function through conformational balance and stability.

DOI 10.1093/molbev/msag204

bacteria (other)deep learning

𝕏 PostBluesky

Molecular BiologyNucleic Acids ResearchPeer-reviewedJan 22, 2020

Cas3 Mediated Target DNA Recognition and Cleavage is Independent of the Composition and Architecture of Cascade Surveillance Complex

Siddharth Nimkar, Baskaran Anand

This study shows that Cas3/I-C cleaves target DNA independently of Cascade composition, revealing conserved mechanisms across type I-C and I-E CRISPR systems.

22 citations

experimental assay

𝕏 PostBluesky