Author

Clayton Hughes

New York Genome CenterORCID 0009-0000-9928-8750Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:clustering· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:phylogenetics / evolution· 1

Frequent Co-Authors

Akira YokoyamaiD· 2 shared Catherine J. PotenskiiD· 2 shared Dan Avi LandauiD· 2 shared Dennis J. YuaniD· 2 shared Jesús Alfonso López SotéloiD· 2 shared John ZinnoiD· 2 shared Julian A. AbramsiD· 2 shared Nobuyuki KakiuchiiD· 2 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenomics

Akira YokoyamaORCID

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2 papers

Recent·Most cited

GenomicsCancer DiscoveryPeer-reviewedDec 31, 2025

Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts

Dennis J. Yuan, John Zinno, Theo Botella…·Dan Avi Landau

The paper develops scG2P to jointly capture DNA mutations and mRNA transcripts in single cells, revealing clonal architectures and phenotypes in aged esophageal tissue.

11 citationstop 4%

humanscRNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintOct 11, 2025

Large-scale single-cell phylogenetic mapping of clonal evolution in the human aging esophagus

Tamara Prieto, Dennis J. Yuan, John Zinno…·Dan Avi Landau

This paper develops SMART-PTA for single-cell whole-genome and transcriptome sequencing, revealing clonal evolution in aged human esophageal tissue over 70 years.

5 citations

humanscRNA-seq

𝕏 PostBluesky