Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts
Dennis J. Yuan, John Zinno, Theo Botella, Dalia M. Dhingra, Shu Wang, Allegra G. Hawkins, Ariel D. Swett, Jesús Alfonso López Sotélo, Ramya Raviram, Clayton Hughes, Catherine J. Potenski, Katharine D. Godfrey, Kara M. Ainsworth, Shuzhen Xu, Jianwen Que, , Dan Avi Landau
The paper develops scG2P to jointly capture DNA mutations and mRNA transcripts in single cells, revealing clonal architectures and phenotypes in aged esophageal tissue.
Cancer Discovery · Dec 31, 2025Peer-reviewedGenomics