Molecular BiologybioRxivPreprint
Highly efficient and specific genome editing in human cells with paired CRISPR-Cas9 nickase ribonucleoproteins
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Author
Merck KGaA, Darmstadt (Germany)ORCID 0009-0001-0581-8325Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
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Yuping Huang, Caitlin McCann, Andrey Samsonov…·Qingzhou Ji
This study shows that linking Cas9 to a cell cycle regulated protein increases the ratio of ssDNA donor integration to NHEJ, improving genome editing precision.