LINC00205 acts as a multivalent scaffold promoting FUSP525L recruitment in Amyotrophic Lateral Sclerosis stress granules
Jessica N. Rea, Gaia Stortini, Tiziana Santini, Adriano Setti, Marta Bernardi, Pierpaolo Cantisani, Letizia Fucci, Davide Mariani, Paolo Tollis, Erika Vitiello, Irene Bozzoni
This study identifies LINC00205 as a critical lncRNA that promotes the formation of pathological stress granules in ALS by acting as a scaffold to recruit specific mRNAs and proteins.
bioRxiv · Apr 9, 2026 · PreprintMolecular Biology