Irene Bozzoni

Neuronal late endosomes serve as selective RNA hubs disrupted by ALS-linked FUS mutation

The paper identifies late endosomes as selective RNA carriers in motor neurons and shows that ALS-linked FUS mutations disrupt this process.

nHOTAIRM1 scaffolds ANXA11-dependent assemblies to drive axonal mRNA localization in human motor neurons

This study identifies nHOTAIRM1's role in axonal mRNA localization by scaffolding ANXA11-dependent transport assemblies in human motor neurons.

LINC00205 acts as a multivalent scaffold promoting FUSP525L recruitment in Amyotrophic Lateral Sclerosis stress granules

This study identifies LINC00205 as a critical lncRNA that promotes the formation of pathological stress granules in ALS by acting as a scaffold to recruit specific mRNAs and proteins.

Mutant FUS perturbs m6A regulation by repressing ALKBH5, while restoring m6A levels alleviates ALS pathology in vivo

This study shows that mutant FUS reduces ALKBH5 expression, increasing m6A levels, and that restoring m6A alleviates ALS pathology in Drosophila models.

A circuit involving the lncRNA MB3 and the driver genes MYC and OTX2 inhibits apoptosis in Group 3 Medulloblastoma by regulating the TGF-β pathway via HMGN5

A Short 63-Nucleotide Element Promotes Efficient circRNA Translation

This study identifies a 63-nucleotide element that promotes efficient circRNA translation, comparable to traditional IRESs, enhancing their therapeutic potential.

Decoding RNA-RNA Interactions: The Role of Low-Complexity Repeats and a Deep Learning Framework for Sequence-Based Prediction

This paper identifies low-complexity repeats as key drivers of RNA-RNA interactions and introduces RIME, a deep learning model that outperforms traditional methods in predicting these interactions.

Live-cell imaging of circular and long non-coding RNAs associated to FUS pathological aggregates by Pepper fluorescent RNA

The paper uses Pepper fluorescent RNA to visualize and study the dynamics of circRNAs and lncRNAs in live cells, revealing their interactions with pathological aggregates and stress granules.

ALS-associated FUS mutation reshapes the RNA and protein composition of Stress Granules.

This study examines how ALS-associated FUS mutations alter the RNA and protein composition of Stress Granules in neural cells, revealing molecular changes linked to neurodegeneration.

M6A reduction relieves FUS-associated ALS granules

The paper shows that reducing m6A content via METTL3 knock-down decreases FUS-associated ALS granules in cell models and patient-derived fibroblasts.

FUS ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention

This study identifies how ALS-causative FUS mutations disrupt RNA processing and autoregulation, with implications for broader ALS genetic interactions.

Dysregulation of circular RNAs in myotonic dystrophy type 1

This study identifies dysregulated circular RNAs in myotonic dystrophy type 1 patients using RNA-sequencing and qPCR, showing tissue-specific expression patterns and potential as biomarkers.