Alexis B. Roberson

The paper quantifies disome levels across the transcriptome in yeast and human cells under basal and stress conditions, showing stress-induced increases and context-dependent redistribution.

This study shows 5-AzaC incorporation into mRNAs disrupts translation, causes ribosome collisions, and activates stress responses, contributing to its cytotoxicity beyond DNA hypomethylation.

This study identifies a reversible feedback mechanism where heme inhibits mature mitochondrial ALAS2, regulating heme synthesis and providing insights into its spatial control.