Trustworthy ML/AI for Aging Clocks: Preventing Systematic Prediction Bias in Biological Age Estimation
H Lee, Zhenyao Ye, Yun Yang, Yezhi Pan, Bradley Maron, Z Wang, Peter V Kochunov, Paul M. Thompson, L Elliot Hong, Tianzhou Ma, Chixiang Chen, Shuo Chen
This paper identifies systematic prediction bias in aging clocks and introduces a constrained optimization framework to improve calibration and downstream inference.
bioRxiv · Sep 6, 2026 · PreprintBioinformatics