The early-life determinant LIN28B constrains immunoglobulin light chain secondary rearrangements independent of BCR specificity
Elena Boldrin, Hugo Åkerstrand, Giorgia Montano, Niklas Krausse, Christine Valfridsson, Stefan Lang, Joan Escrivà-Font, Camila Rosat Consiglio, Shamit Soneji, Joan Yuan
This study shows LIN28B restricts IgL secondary rearrangements in B cells independently of BCR specificity, shaping early-life immunoglobulin repertoire bias.
bioRxiv · Sep 8, 2026 · PreprintImmunology