Shamit Soneji

The early-life determinant LIN28B constrains immunoglobulin light chain secondary rearrangements independent of BCR specificity

This study shows LIN28B restricts IgL secondary rearrangements in B cells independently of BCR specificity, shaping early-life immunoglobulin repertoire bias.

Chromatin Accessibility Shapes Developmental-Specific Lineage Plasticity in Hematopoiesis

The paper shows fetal hematopoietic stem and progenitor cells (HSPCs) have greater lineage plasticity than adult HSPCs, linked to chromatin accessibility differences.

Transcriptional Roadmap of the Human Airway Epithelium Identifying HLF as a Novel Regulator of Basal Stem Cell Function

The paper maps the transcriptional landscape of the human airway epithelium and identifies HLF as a regulator of basal stem cell function and tumor suppression.

A Combined Immunophenotypic And Transcriptional Single-Cell Map Of First Trimester Human Fetal Liver Hematopoiesis

The paper presents a single-cell map of first trimester human fetal liver hematopoiesis, identifying molecular and immunophenotypic differences from adult cells and linking findings to pediatric leukemia.

Scarf: A toolkit for memory efficient analysis of large-scale single-cell genomics data

Scarf provides a memory-efficient toolkit for analyzing large-scale single-cell genomics data on standard hardware.

CellexalVR: A virtual reality platform to visualise and analyse single-cell data

CellexalVR provides a virtual reality platform for visualizing and analyzing single-cell data, enabling intuitive and collaborative exploration of complex datasets.

Nabo - a framework to define leukemia-initiating cells and differentiation in single-cell RNA-sequencing data

Nabo maps cells from one population to the most similar cells in a reference population, improving accuracy in identifying tumor-initiating cells in single-cell RNA-Seq data.

HSCs contribute actively to native multilineage hematopoiesis but with reduced differentiation capacity upon aging

This study shows that adult HSCs contribute to all blood lineages in steady state but decline in contribution with age due to reduced differentiation capacity.