NeurosciencebioRxivPreprint
Young adult microglial deletion of C1q reduces engulfment of synapses and prevents cognitive impairment in an aggressive Alzheimer's disease mouse model
Tiffany J. Petrisko, Shu‐Hui Chu, Ángela Gómez-Arboledas…·Andrea J. Tenner
This study shows that deleting microglial C1q in young adult Alzheimer's mice reduces synaptic engulfment and preserves cognition without affecting amyloid levels.
DOI 10.1101/2025.09.13.676049