Low-coverage whole-genome sequencing facilitates accurate and cost-effective haplotype reconstruction in complex mouse crosses
Samuel J. Widmayer, Lydia K. Wooldridge, Emily Swanzey, Mary E. Barter, Chrystal Snow, Michael C. Saul, Qingchang Meng, Beth L. Dumont, Laura G. Reinholdt, Daniel M. Gatti
This study shows that low-coverage whole-genome sequencing (lcWGS) accurately reconstructs haplotypes in complex mouse crosses, outperforming SNP arrays and ddRADseq at low sequencing depths.
Mammalian Genome · Jul 1, 2025Peer-reviewedGenetics