Michael C. Saul

This study identifies a shared genetic regulator linking metabolism and addiction-related behavior in mice and humans through a common enhancer regulating Eed/Me3 and EED/ME3.

This study shows that multi-week digital home cage monitoring in rodents improves reproducibility by reducing noise and enhancing replication of genotype differences in activity.

The paper examines behavioral variation in cocaine self-administration across multiple phases in genetically diverse mouse populations, identifying strain and sex differences and extreme strains for drug intake traits.

This study shows that low-coverage whole-genome sequencing (lcWGS) accurately reconstructs haplotypes in complex mouse crosses, outperforming SNP arrays and ddRADseq at low sequencing depths.

The paper identifies a genetic locus and protein associated with resilience to cognitive decline in AD-BXD mice and links it to human AD traits.

This study maps eQTLs in the striatum of Diversity Outbred mice and provides tools for querying genetic variants and co-expression networks related to striatal gene expression and addiction-related behaviors.

RNA Strain-Match matches RNA sequencing alignment data to genotype without variant call files, correcting 13% of sample mismatches in mouse models.

This study shows that including genetic and sex differences in mice improves the alignment of addiction-related traits with human studies.

The paper identifies conserved neurogenomic response toolkits across species using multi-species transcriptomic analysis and systems-level functional grouping.