Beth L. Dumont

This study shows that genetically distinct tumor microenvironments in mice affect cancer growth, survival, and therapy response, independent of cancer cell properties or immune system.

The paper benchmarks variant calling tools in inbred mouse strains, finding tradeoffs between recall and precision and recommending ensemble approaches for optimal results.

The paper analyzes young KRAB-zinc finger gene clusters in mice, showing ERVs drive genetic heterogeneity through recombination and duplication mechanisms.

This study shows that low-coverage whole-genome sequencing (lcWGS) accurately reconstructs haplotypes in complex mouse crosses, outperforming SNP arrays and ddRADseq at low sequencing depths.

This study finds a ~30% increase in de novo single nucleotide mutations in house mice conceived via assisted reproductive technologies compared to naturally conceived mice.

This study shows male and female recombination rates in house mice evolve under distinct evolutionary programs, with males showing a unique adaptive optimum in their lineage.

This study updates the geographic range of house mice using biodiversity data and genetic analysis, revealing their environmental limits and ancestral origins in South Asia.

This study investigates the molecular evolution of the kinetochore complex across primate and rodent species, finding adaptive evolution in many core components and highlighting the role of centromere features in driving protein evolution.

The paper introduces 11 wild-derived inbred mouse strains with expanded genomic and phenotypic diversity, enhancing the scope of biomedical research.

The paper describes a novel centromere structure in the mouse species Mus pahari, characterized by a divergent repeat and unique CENP-B recruitment, enabling high-fidelity segregation during cell division.

The paper constructs fine-scale recombination maps in wild house mouse populations and finds weak conservation across subspecies and population-specific differences in recombination patterns.

The paper investigates strain-level variation in CENP-A association with centromeres in mice, finding strain-specific differences that challenge the idea that centromere function depends solely on satellite array size.

The paper uses linked-read whole-genome sequencing to identify DNA variants in BXD mice and maps them to phenotypes, enabling systems genetics and precision medicine.

The paper quantifies sex ratio distortion in CC mouse strains and shows it arises from multilocus interactions of selfish sex-linked elements.

The paper quantifies centromere sequence variation across mouse genomes and finds rapid evolution and inbreeding effects on centromere architecture.

The paper shows that sex-specific modifiers, like CHK2, allow female fertility without PRDM9, revealing sex-specific regulation of meiotic recombination.