Gabrielle E. Shakt

This study identifies 243 genome-wide significant loci for hernia subtypes, reveals shared and distinct genetic factors, and identifies potential therapeutic targets.

This study shows that angiographic CAD burden independently contributes to adverse cardiovascular outcomes, even when traditional risk factors are accounted for.

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

This paper evaluates adding polygenic risk scores to the RECODe model for predicting cardiovascular outcomes in type 2 diabetes patients, finding no significant improvement in predictive performance.