Author

Siegfried Dubois

Centre National de la Recherche ScientifiqueORCID 0009-0001-9800-0644Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 3

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 3 Organism:human· 2 Approach:simulation· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:variant calling· 1 Organism:yeast· 1

Frequent Co-Authors

Claire LemaitreiD· 2 shared Benjamin LinardiD· 1 shared Fabrice LegeaiiD· 1 shared Lucien PiatiD· 1 shared Ludovic DuvauxiD· 1 shared Matthias ZytnickiiD· 1 shared Sandra J. RomainiD· 1 shared Sukanya Denni· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 12 mutual co-author links

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2 shared papersBioinformatics

Claire LemaitreORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 3, 2026

Simulating population pangenomes under coalescent demographic models with MSpangenome

Lucien Piat, Sukanya Denni, Siegfried Dubois…·Ludovic Duvaux

MSpangenome simulates population pangenomes from coalescent demographic models to benchmark graph construction tools.

1 citation

simulationbenchmarking

𝕏 PostBluesky

BioinformaticsBioinformaticsPeer-reviewedMay 8, 2025

Pairwise graph edit distance characterizes the impact of the construction method on pangenome graphs

Siegfried Dubois, Matthias Zytnicki, Claire Lemaitre, Thomas Faraut

The paper introduces a method to measure differences between pangenome graphs using pairwise graph edit distance and applies it to yeast and human datasets.

6 citations

𝕏 PostBluesky

BioinformaticsbioRxivPreprintMar 14, 2025

Investigating the topological motifs of inversions in pangenome graphs

Sandra J. Romain, Siegfried Dubois, Fabrice Legeai, Claire Lemaitre

The paper investigates inversion topological motifs in pangenome graphs and finds significant variation in inversion representation across pipelines, with poor recovery in real human data.

5 citations

humanwhole-genome sequencing

𝕏 PostBluesky