Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1
Tsukasa Makino, Ryo Kanada, Teppei Mori, Ken‐ichi Miyazono, Yuta Komori, Haruaki Yanagisawa, Shoji Takada, Masaru Tanokura, Masahide Kikkawa, Michio Tomishige
This study shows that tension in the neck linker of kinesin-1 suppresses premature binding of the detached head, explaining coordinated stepping through allosteric regulation.
The Journal of Cell Biology · Apr 9, 2025Peer-reviewedBiophysics