Masahide Kikkawa

The paper reports a cryo-EM structure of P301L/S320F double-mutant tau filaments induced in mice via peripheral AAV delivery, revealing a novel filament fold distinct from known tauopathies.

The paper investigates how CCDC32 interacts with AP-2 to regulate its assembly, revealing that CCDC32 inhibits assembly and requires membrane binding for complex formation.

The paper demonstrates atomic resolution cryo-EM at 200 kV using upgraded hardware, achieving 1.24 Å resolution comparable to 300 kV systems.

The paper investigates structural convergence in fusion enzymes from different gene fusions, showing similar dimeric structures despite distinct overall architectures and amino acid sequences.

The paper determines the structure of PMEL amyloids using cryo-EM and shows how the G175S mutation increases amyloid formation, contributing to pigment dispersion syndrome.

This study shows that tension in the neck linker of kinesin-1 suppresses premature binding of the detached head, explaining coordinated stepping through allosteric regulation.

This study presents cryo-EM structures of GAS2 domains bound to actin and microtubules, revealing their roles in cytoskeletal organization and dimerization.

The paper identifies the Hitchdock domain in kinesin-2 tail as critical for adaptor assembly and cargo binding, revealing its structural role in interactions with KAP3 and APC.

The paper uses cryo-ET and non-averaging analysis to reveal heterogeneous local structures of microtubules, showing polymerizing and depolymerizing ends share similar lattice spacing but differ in twisting.

The paper presents cryo-EM structures of human ZnT7, revealing its mechanism for Zn2+ uptake into the Golgi apparatus through conformational changes and histidine-rich loop interactions.

The paper presents the cryo-EM structure of the human LRRC8A protein, revealing its trimer-of-dimers assembly and structural features relevant to its function as a volume-regulated anion channel.