Author

Tsukasa Makino

The University of TokyoORCID 0000-0002-9134-6669Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Masahide KikkawaiD· 2 shared Akihiro NaritaiD· 1 shared Haruaki YanagisawaiD· 1 shared J. AniD· 1 shared Ken‐ichi MiyazonoiD· 1 shared Masaru TanokuraiD· 1 shared Michio TomishigeiD· 1 shared Ryo KanadaiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiophysics

Masahide KikkawaORCID

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2 papers

Recent·Most cited

Tension-induced suppression of allosteric conformational changes explains coordinated stepping of kinesin-1

Tsukasa Makino, Ryo Kanada, Teppei Mori, Ken‐ichi Miyazono, Yuta Komori, Haruaki Yanagisawa, Shoji Takada, Masaru Tanokura, Masahide Kikkawa, Michio Tomishige

This study shows that tension in the neck linker of kinesin-1 suppresses premature binding of the detached head, explaining coordinated stepping through allosteric regulation.

The Journal of Cell Biology · Apr 9, 2025Peer-reviewedBiophysics

Dimerization GAS2 mediates microtubule and F-actin crosslinking

J. An, Tsuyoshi Imasaki, Akihiro Narita, Shinsuke Niwa, Ryohei Sasaki, Tsukasa Makino, Ryo Nitta, Masahide Kikkawa

This study presents cryo-EM structures of GAS2 domains bound to actin and microtubules, revealing their roles in cytoskeletal organization and dimerization.

The EMBO Journal · Apr 1, 2025Peer-reviewedBiochemistry