The phosphodiesterase-5 inhibitor vardenafil reverses sleep deprivation-induced amnesia in mice
Camilla Paraciani, Carlo Castoldi, Diana Madalina Popescu, Elroy L. Meijer, Onno Cornelis Van Den Hoed, Adithya Sarma, Sophia A. Wilhelm, Nienke de Vries, Linda Maria Requie, Esmée D’Costa, Dimitrios Tantis Tapeinos, Pim R.A. Heckman, Ewelina Knapska, Peter Meerlo, Bianca Ambrogina Silva, Robbert Havekes
This paper shows that vardenafil, a PDE5 inhibitor, can reverse sleep deprivation-induced amnesia in mice when combined with optogenetic engram stimulation, enhancing memory reactivation in the dentate gyrus.
bioRxiv · Mar 26, 2026 · PreprintNeuroscience