Author

Pim R.A. Heckman

Maastricht UniversityORCID 0000-0002-7319-8690Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

Camilla ParacianiiD· 2 shared Elroy L. MeijeriD· 2 shared Peter MeerloiD· 2 shared Robbert HavekesiD· 2 shared Sophia A. WilhelmiD· 2 shared Adithya SarmaiD· 1 shared Bianca Ambrogina SilvaiD· 1 shared Carlo CastoldiiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Camilla ParacianiORCID

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2 papers

Recent·Most cited

The phosphodiesterase-5 inhibitor vardenafil reverses sleep deprivation-induced amnesia in mice

Camilla Paraciani, Carlo Castoldi, Diana Madalina Popescu, Elroy L. Meijer, Onno Cornelis Van Den Hoed, Adithya Sarma, Sophia A. Wilhelm, Nienke de Vries, Linda Maria Requie, Esmée D’Costa, Dimitrios Tantis Tapeinos, Pim R.A. Heckman, Ewelina Knapska, Peter Meerlo, Bianca Ambrogina Silva, Robbert Havekes

This paper shows that vardenafil, a PDE5 inhibitor, can reverse sleep deprivation-induced amnesia in mice when combined with optogenetic engram stimulation, enhancing memory reactivation in the dentate gyrus.

bioRxiv · Mar 26, 2026 · PreprintNeuroscience

Restoring persistent accessibility to memories after sleep deprivation-induced amnesia

Youri G. Bolsius, Pim R.A. Heckman, Camilla Paraciani, Sophia A. Wilhelm, Frank Raven, Elroy L. Meijer, Martien J. Kas, Steve Ramirez, Peter Meerlo, Robbert Havekes

This study shows that sleep deprivation does not cause memory loss but suboptimal storage, which can be retrieved using optogenetics or roflumilast.

Current Biology · Dec 27, 2022Peer-reviewedNeuroscience