Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets
Simon T. Herrmann, Timon Kapischke, Saskia Westhoven, Natalie Heinen, Luca D. Bertzbach, Toni Luise Meister, Barbara Sitek, Thilo Bracht, Stephanie Pfaender, Lars Kaderali
The paper models SARS-CoV-2 replication dynamics in human cells, identifies key bottlenecks, and evaluates antiviral drug effects using mathematical modeling and experimental data.
bioRxiv · Aug 26, 2026 · PreprintMicrobiology