Author

Stephanie Pfaender

Ruhr University BochumORCID 0000-0002-3957-5448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:mechanistic / dynamical model· 1 Assay:proteomics· 1

Frequent Co-Authors

Antje DickmannsiD· 2 shared Dirk GörlichiD· 2 shared Kim M. StegmanniD· 2 shared Matthias DobbelsteiniD· 2 shared Natalie HeineniD· 2 shared Simon T. HerrmanniD· 2 shared Toni Luise MeisteriD· 2 shared Uwe GroßiD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersMolecular Biology

Antje DickmannsORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintAug 26, 2026

Quantitative modeling of SARS-CoV-2 replication reveals phase-specific bottlenecks and antiviral targets

Simon T. Herrmann, Timon Kapischke, Saskia Westhoven…·Lars Kaderali

The paper models SARS-CoV-2 replication dynamics in human cells, identifies key bottlenecks, and evaluates antiviral drug effects using mathematical modeling and experimental data.

DOI 10.64898/2026.06.23.733955

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintJun 28, 2021

N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication

Kim M. Stegmann, Antje Dickmanns, Natalie Heinen…·Matthias Dobbelstein

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

8 citations

experimental assay

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Molecular BiologyVirus ResearchPeer-reviewedJun 6, 2021

The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber…·Matthias Dobbelstein

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.

50 citations

humanbulk RNA-seq

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