Telomeric amplicons of SUL1 and Y' in yeast are generated by microhomology-mediated break induced replication occurring in cis
Bonita J. Brewer, Rebecca Martin, Elizabeth R. Ramage, Célia Payen, Sara C. Di Rienzi, Yang Zhao, Kelsey Zane, Jocelyn Verhey, Miranda Galey, Danny E. Miller, Giang T. Ong, Jamie L. McKee, Gina M. Alvino, Maitreya J. Dunham, M. K. Raghuraman
The paper identifies a mechanism of gene amplification in yeast involving microhomology-mediated break-induced replication (mmBIR) at telomeres, leading to tandem duplication of chromosomal ends.
PLoS Genetics · Aug 20, 2026Peer-reviewedGenetics