Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKD
Ming Wu, Yanzhe Wang, Ying Jing, Dong‐Ping Chen, Yufeng Xing, Yanfang Bai, Di Huang, Yijing Zhou, Jinghua Hu, Shougang Zhuang, Chaoyang Ye
This study shows that upregulation of polycystins in fibrotic kidneys promotes renal fibrosis and cyst growth in ADPKD mice, and that inhibiting polycystins reduces fibrosis and cyst progression.
bioRxiv · Nov 3, 2021 · PreprintMolecular Biology