Jinghua Hu

Identification of candidate ciliary microtubule-associated proteins using CEP41 proximity labeling

The paper identifies novel ciliary microtubule-associated proteins using BioID proximity labeling and proteomics, expanding the known repertoire of ciliary MAPs.

Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKD

This study shows that upregulation of polycystins in fibrotic kidneys promotes renal fibrosis and cyst growth in ADPKD mice, and that inhibiting polycystins reduces fibrosis and cyst progression.

An extracellular protein regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans

This study identifies DYF-4 as a glia-secreted protein that interacts with DAF-6 to regulate glial channel formation and neuronal development in C. elegans.