Author

Dong‐Ping Chen

Shanghai University of Traditional Chinese MedicineORCID 0000-0002-3103-5308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Chaoyang YeiD· 2 shared Di HuangiD· 2 shared Ming WuiD· 2 shared Bo TaniD· 1 shared Feng YangiD· 1 shared Guangyu Sheng· 1 shared Jinghua HuiD· 1 shared Junyan LiniD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersMolecular Biology

Chaoyang YeORCID

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2 papers

Recent·Most cited

Epigenetically silencing gluconeogenic enzyme PCK1 by EZH2 promotes renal tubulointerstitial fibrosis

Ming Wu, Dong‐Ping Chen, Yanzhe Wang, Pinglan Lin, Feng Yang, Junyan Lin, Bo Tan, Guangyu Sheng, Xuejun Yang, Di Huang, Chaoyang Ye

This study shows that EZH2 epigenetically suppresses PCK1, a gluconeogenic enzyme, promoting renal fibrosis, and that restoring PCK1 reduces fibrosis in CKD models.

bioRxiv · Oct 31, 2022 · PreprintMolecular Biology

Tubular obstruction induced polycystin upregulation is pro-fibrotic and induced a severe cystic phenotype in adult mice with autosomal dominant polycystic kidney disease: the coexistence of polycystin loss and gain function in ADPKD

Ming Wu, Yanzhe Wang, Ying Jing, Dong‐Ping Chen, Yufeng Xing, Yanfang Bai, Di Huang, Yijing Zhou, Jinghua Hu, Shougang Zhuang, Chaoyang Ye

This study shows that upregulation of polycystins in fibrotic kidneys promotes renal fibrosis and cyst growth in ADPKD mice, and that inhibiting polycystins reduces fibrosis and cyst progression.

bioRxiv · Nov 3, 2021 · PreprintMolecular Biology