Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant negative manner
Paige Blinkiewicz, Nicole C Hoenes, Muhammad Zubair Afzal, Yihong Liu, Ulysses J Hill, Sophie K. Trafton, Berglind Bjarnadottir, Tucker Burgin, Prerna Malaney
This study shows that colorectal cancer-associated PCBP1 mutations destabilize the protein and act as dominant-negative variants, inactivating the tumor suppressor function.
Journal of Biological Chemistry · Jul 28, 2026Peer-reviewedCancer Biology