Tucker Burgin

The paper demonstrates that chemical rescue is a predictive proxy for glycosynthase activity, validated through correlation with enzymatic activity and transition state analysis.

This study shows that colorectal cancer-associated PCBP1 mutations destabilize the protein and act as dominant-negative variants, inactivating the tumor suppressor function.

This study investigates INF2 regulation by calcium-calmodulin and actin monomers, showing that actin monomer-binding proteins are essential for INF2 activation and regulation.

This paper introduces a method to guide protein engineering using machine learning that leverages dynamics-property relationships from molecular dynamics simulations with minimal experimental data.