Prerna Malaney

Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant negative manner

This study shows that colorectal cancer-associated PCBP1 mutations destabilize the protein and act as dominant-negative variants, inactivating the tumor suppressor function.

The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

This study identifies Hnrnpk as a master regulator of nucleolar stress and ribosome impairment, linking nucleolar abnormalities to aging and bone marrow failure.

Adar1 deletion causes degeneration of exocrine pancreas via Mavs-dependent interferon signaling

This study shows that Adar1 deletion in mice causes exocrine pancreas degeneration through Mavs-dependent interferon signaling, which is rescued by concurrent Mavs deletion.